What Is Spermidine And What Is The Use of Spermidine Supplement?

Polyamines are organic compounds essential for many cellular functions, including DNA and protein synthesis, gene regulation, and cell proliferation. Aliphatic polyamines are a subclass of polyamines that contain linear carbon chains, such as spermidine, putrescine, and spermine.

It is a naturally occurring aliphatic polyamine compound found in all living organisms. It is synthesized from putrescine by the action of the enzyme synthase. This aliphatic polyamine compound is present in various foods, such as wheat germ, soybeans, and mushrooms, and can also be produced by the human body.

It has been found to have many health benefits, including anti-aging properties, neuroprotection, and cardioprotection. It has recently gained attention as a dietary supplement due to its potential to enhance health and longevity. Explored below are some of its widely known benefits along with its food sources:

Food Sources Of Aliphatic Polyamine Compound 

This compound is found in various foods, including fruits, vegetables, and grains. Some of its richest sources include soybeans, mushrooms, wheat germ, and aged cheese. Additionally, fermented foods such as yogurt, kimchi, and sauerkraut are good sources of this aliphatic polyamine compound. While dietary supplements may be a convenient way to increase their intake, it is essential to remember that a balanced diet that includes a variety of spermidine-rich foods is the best way to obtain optimal amounts of this compound.

Anti-Aging Properties

This compound promotes autophagy, a process in which damaged or dysfunctional cellular components are broken down and recycled. Several studies have demonstrated that spermidine supplementation can increase autophagy in various organisms, including yeast, fruit flies, and mice. In a study published, researchers found that its supplementation extended the lifespan of mice and improved their cardiovascular health. The researchers hypothesized that aliphatic polyamine compound-induced autophagy was responsible for these beneficial effects.

Neuroprotective Effects

This aliphatic polyamine compound has been shown to protect against neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. This protein accumulates in the brains of Alzheimer’s patients. Researchers have concluded that this compound might have therapeutic potential for treating Alzheimer’s disease. 

Cardioprotective Effects

Aliphatic polyamine compound has been shown to have cardioprotective effects by improving cardiovascular health and reducing the risk of heart disease. In a published study, researchers found that this compound supplementation reduced blood pressure and improved heart function in mice with hypertension. It could be a treatment for hypertension and other cardiovascular diseases.

Boosted Immune System

An aliphatic polyamine compound supplementation boosts the immune system by enhancing the activity of immune cells, such as natural killer cells and T cells. In a study involving elderly individuals, this three-month supplementation improved immune function and reduced the incidence of infections.

Summing Up

In conclusion, spermidine is a naturally occurring aliphatic polyamine compound synthesized by all living organisms and has numerous health benefits. Its supplementation has been shown to have anti-aging properties, improve cardiovascular health, enhance cognitive function, and boost the immune system. It is important to note that while aliphatic polyamine compound supplementation has shown promising results in preclinical and clinical studies, more research is needed to understand its mechanisms of action and potential long-term effects fully.

If you are considering taking a supplement, it is essential to consult with a healthcare professional to determine if it is right for you. Additionally, choosing a high-quality supplement from a reputable manufacturer is crucial to ensure you get a safe and effective product.